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Compound Detail

CHEMBL75126

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CSc1sc(C(=O)NN)c2c1C=CCC2

Basic Information

ChEMBL ID CHEMBL75126
Phase Preclinical
Structure Type MOL
InChI Key JKZGSVSZMWRNFW-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

240.3
MW (Da)
2.03
ALogP
4
HBA
2
HBD
55.1
PSA (Ų)
0.36
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C10H12N2OS2
MW 240.35
Aromatic Rings 1
Heavy Atoms 15
NP-Likeness -0.47

Activity Summary

Ki 3 meas. best 4.89

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A3
CHEMBL256
Ki 4.89 4.89 13000.0 1
Adenosine receptor A3
CHEMBL3360
Ki 4.88 4.88 13100.0 1
Adenosine receptor A1
CHEMBL318
Ki 4.29 4.29 51600.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
8558508 10.1021/jm9504823 Adenosine receptor A1 1
8558508 10.1021/jm9504823 Adenosine receptor A2a 1
8558508 10.1021/jm9504823 Adenosine receptor A3 1
8558508 10.1021/jm9504823 Adenosine receptors; A1 & A2a 1
8558508 10.1021/jm9504823 Unchecked 1
8691424 10.1021/jm950923i Adenosine receptor A3 1

Data from ChEMBL 36 via Core Engine