Assay Detail
Binding
CHEMBL641504
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Binding affinity against AMPA receptor in rat brain membrane using [3H]-AMPA as radioligand
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, AMPA (CHEMBL2093871) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-quinoxalinedione hydrochloride (YM90K) and related compounds: structure-activity relationships for the AMPA-type non-NMDA receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 6.31 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222519 | NBQX | — | 1 | 7.22 |
| CHEMBL13260 | YM-90K | — | 1 | 7.08 |
| CHEMBL357841 | — | — | 1 | 7.00 |
| CHEMBL129227 | — | — | 1 | 6.75 |
| CHEMBL142005 | — | — | 1 | 6.70 |
| CHEMBL62431 | — | — | 1 | 6.70 |
| CHEMBL155265 | DNQX | — | 1 | 6.70 |
| CHEMBL142391 | — | — | 1 | 6.64 |
| CHEMBL128118 | — | — | 1 | 6.62 |
| CHEMBL9790 | — | — | 1 | 6.57 |
| CHEMBL142233 | — | — | 1 | 6.41 |
| CHEMBL294540 | — | — | 1 | 6.37 |
| CHEMBL410513 | — | — | 1 | 6.21 |
| CHEMBL142872 | — | — | 1 | 6.16 |
| CHEMBL345094 | — | — | 1 | 6.09 |
| CHEMBL142804 | — | — | 1 | 5.89 |
| CHEMBL145604 | — | — | 1 | 5.85 |
| CHEMBL27715 | — | — | 1 | 5.80 |
| CHEMBL337747 | — | — | 1 | 5.72 |
| CHEMBL23044 | — | — | 1 | 5.70 |
| CHEMBL142157 | — | — | 1 | 5.32 |
| CHEMBL342289 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222519 | NBQX | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL13260 | YM-90K | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL357841 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL129227 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL142005 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL62431 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL155265 | DNQX | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL142391 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL128118 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL9790 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL142233 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL294540 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL410513 | — | Ki | = | 620.0 | nM | 6.21 |
| CHEMBL142872 | — | Ki | = | 690.0 | nM | 6.16 |
| CHEMBL345094 | — | Ki | = | 820.0 | nM | 6.09 |
| CHEMBL142804 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL145604 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL27715 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL337747 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL23044 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL142157 | — | Ki | = | 4800.0 | nM | 5.32 |
| CHEMBL342289 | — | Ki | = | 5000.0 | nM | 5.30 |