Compound Detail
CHEMBL27715
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Basic Information
| ChEMBL ID | CHEMBL27715 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AWSQFCTXRSLXRJ-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
228.2
MW (Da)
1.23
ALogP
6
HBA
2
HBD
84.1
PSA (Ų)
0.65
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 5.8
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA CHEMBL2093871 | Ki | 5.8 | 5.8 | 1600.0 | 2 |
| Unchecked CHEMBL612545 | Ki | 5.8 | 5.8 | 1600.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA | Ki | = | 1600.0 | nM | 5.8 | Binding affinity against AMPA receptor in rat brain membrane using [3H]-AMPA as ... | 8120865 |
| Glutamate receptor ionotropic, AMPA | Ki | = | 1600.0 | nM | 5.8 | In vitro inhibition of the specific binding of [3H]AMPA to Ionotropic glutamate ... | 8632440 |
| Unchecked | Ki | = | 1600.0 | nM | 5.8 | Displacement of [3H]AMPA from AMPA receptor in rat cortical membrane | 20356304 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8120865 | 10.1021/jm00030a006 | Glutamate receptor ionotropic, AMPA | 1 |
| 8632440 | 10.1021/jm950304+ | Glutamate receptor ionotropic, AMPA | 1 |
| 20356304 | 10.1021/jm901688m | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine