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Assay Detail

CHEMBL642007

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Agonistic activity measures the ability to induce alkaline phosphatase in T47D human breast cancer cell line
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Cell Type T47D
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Progesterone receptor (CHEMBL208)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Novel pyrrole-containing progesterone receptor modulators.
Collins MA, Hudak V, Bender R, Fensome A, Zhang P, Miller L, Winneker RC, Zhang Z, Zhu Y, Cohen J, Unwalla RJ, Wrobel J.
Bioorg Med Chem Lett (2004) 14 : 2185 -2189
PubMed 15081005 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 19 8.13 9.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL717 MEDROXYPROGESTERONE ACETATE 4.0 1 9.30
CHEMBL305946 1 8.68
CHEMBL305298 1 8.55
CHEMBL303851 1 7.22
CHEMBL71456 1 6.89
CHEMBL308938 1 -
CHEMBL71526 1 -
CHEMBL70820 1 -
CHEMBL303209 1 -
CHEMBL67914 1 -
CHEMBL69384 1 -
CHEMBL71984 1 -
CHEMBL71527 1 -
CHEMBL70018 1 -
CHEMBL304815 1 -
CHEMBL70114 1 -
CHEMBL71896 1 -
CHEMBL307080 1 -
CHEMBL303642 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL717 MEDROXYPROGESTERONE ACETATE EC50 = 0.5 nM 9.30
CHEMBL305946 EC50 = 2.1 nM 8.68
CHEMBL305298 EC50 = 2.8 nM 8.55
CHEMBL303851 EC50 = 60.0 nM 7.22
CHEMBL71456 EC50 = 130.0 nM 6.89
CHEMBL308938 EC50 ~ 1000.0 nM -
CHEMBL71526 EC50 > 1000.0 nM -
CHEMBL70820 EC50 ~ 3000.0 nM -
CHEMBL303209 EC50 ~ 1000.0 nM -
CHEMBL67914 EC50 ~ 1000.0 nM -
CHEMBL69384 EC50 > 3000.0 nM -
CHEMBL71984 EC50 > 1000.0 nM -
CHEMBL71527 EC50 ~ 1000.0 nM -
CHEMBL70018 EC50 ~ 1000.0 nM -
CHEMBL304815 EC50 > 1000.0 nM -
CHEMBL70114 EC50 > 1000.0 nM -
CHEMBL71896 EC50 > 1000.0 nM -
CHEMBL307080 EC50 > 1000.0 nM -
CHEMBL303642 EC50 ~ 1000.0 nM -