Assay Detail
Binding
CHEMBL642011
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Inhibition of [3H]ZM-241385 binding to human adenosine A2B receptor
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
1,8-disubstituted xanthine derivatives: synthesis of potent A2B-selective adenosine receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 35 | 7.84 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL416417 | — | — | 1 | 8.92 |
| CHEMBL37726 | — | — | 1 | 8.92 |
| CHEMBL38304 | — | — | 1 | 8.89 |
| CHEMBL36963 | — | — | 1 | 8.60 |
| CHEMBL34762 | — | — | 1 | 8.57 |
| CHEMBL416963 | — | — | 1 | 8.54 |
| CHEMBL284288 | — | — | 1 | 8.43 |
| CHEMBL40055 | — | — | 1 | 8.42 |
| CHEMBL35701 | — | — | 1 | 8.36 |
| CHEMBL274855 | — | — | 1 | 8.33 |
| CHEMBL38193 | — | — | 1 | 8.28 |
| CHEMBL37875 | — | — | 1 | 8.26 |
| CHEMBL37933 | — | — | 1 | 8.21 |
| CHEMBL37050 | — | — | 1 | 8.19 |
| CHEMBL286527 | — | — | 1 | 8.17 |
| CHEMBL288459 | — | — | 1 | 8.00 |
| CHEMBL37082 | — | — | 1 | 7.97 |
| CHEMBL8789 | — | — | 1 | 7.93 |
| CHEMBL286350 | — | — | 1 | 7.89 |
| CHEMBL37987 | — | — | 1 | 7.84 |
| CHEMBL34543 | — | — | 1 | 7.83 |
| CHEMBL2113345 | — | — | 1 | 7.82 |
| CHEMBL287129 | — | — | 1 | 7.72 |
| CHEMBL35094 | — | — | 1 | 7.62 |
| CHEMBL289516 | — | — | 1 | 7.58 |
| CHEMBL37243 | — | — | 1 | 7.46 |
| CHEMBL35415 | — | — | 1 | 7.38 |
| CHEMBL183 | 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX] | — | 1 | 7.29 |
| CHEMBL34862 | — | — | 1 | 7.27 |
| CHEMBL16997 | — | — | 1 | 7.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL416417 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL37726 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL38304 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL36963 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL34762 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL416963 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL284288 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL40055 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL35701 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL274855 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL38193 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL37875 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL37933 | — | Ki | = | 6.1 | nM | 8.21 |
| CHEMBL37050 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL286527 | — | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL288459 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL37082 | — | Ki | = | 10.8 | nM | 7.97 |
| CHEMBL8789 | — | Ki | = | 11.8 | nM | 7.93 |
| CHEMBL286350 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL37987 | — | Ki | = | 14.5 | nM | 7.84 |
| CHEMBL34543 | — | Ki | = | 14.7 | nM | 7.83 |
| CHEMBL2113345 | — | Ki | = | 15.1 | nM | 7.82 |
| CHEMBL287129 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL35094 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL289516 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL37243 | — | Ki | = | 34.4 | nM | 7.46 |
| CHEMBL35415 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL183 | 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX] | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL34862 | — | Ki | = | 53.4 | nM | 7.27 |
| CHEMBL16997 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL36952 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL435575 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL37621 | — | Ki | = | 372.0 | nM | 6.43 |
| CHEMBL284991 | — | Ki | = | 520.0 | nM | 6.28 |
| CHEMBL285191 | — | Ki | = | 810.0 | nM | 6.09 |