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Compound Detail

CHEMBL35415

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CCCn1c(=O)[nH]c2cc(-c3ccccc3)[nH]c2c1=O

Basic Information

ChEMBL ID CHEMBL35415
Phase Preclinical
Structure Type MOL
InChI Key BPDPDYKJBCCINO-UHFFFAOYSA-N
6
Targets
7
Activities
1
Assay Types
0
PK Parameters
10
Publications
0
Known Names

Molecular Properties

269.3
MW (Da)
2.09
ALogP
3
HBA
2
HBD
70.7
PSA (Ų)
0.76
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C15H15N3O2
MW 269.30
Aromatic Rings 3
Heavy Atoms 20
NP-Likeness -0.98

Activity Summary

Ki 7 meas. best 7.41

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A1
CHEMBL318
Ki 7.41 7.41 39.0 2
Adenosine receptor A2b
CHEMBL255
Ki 7.38 7.38 42.0 1
Adenosine receptor A1
CHEMBL226
Ki 7.35 7.35 45.0 1
Adenosine receptor A3
CHEMBL256
Ki 6.42 6.42 380.0 1
Adenosine A2 receptor
CHEMBL2094117
Ki 5.92 5.92 1200.0 1
Adenosine receptor A2a
CHEMBL302
Ki 5.92 5.92 1200.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
11906291 10.1021/jm011049y Adenosine receptor A1 2
11906291 10.1021/jm011049y Adenosine receptor A2a 2
8182711 10.1021/jm00036a019 Adenosine receptor A1 1
8182711 10.1021/jm00036a019 Adenosine A2 receptor 1
8182711 10.1021/jm00036a019 Adenosine receptors; A1 & A2 1
11906291 10.1021/jm011049y Adenosine receptor A2b 1
11906291 10.1021/jm011049y Adenosine receptor A3 1
11906291 10.1021/jm011049y Adenosine receptors; A1 & A2b 1
11906291 10.1021/jm011049y Adenosine A2 receptor 1
11906291 10.1021/jm011049y Adenosine receptors; A2b & A3 1

Data from ChEMBL 36 via Core Engine