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Compound Detail

CHEMBL284991

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Cn1c(=O)[nH]c2cc(-c3ccccc3)[nH]c2c1=O

Basic Information

ChEMBL ID CHEMBL284991
Phase Preclinical
Structure Type MOL
InChI Key OCIVKCYXPVPVPT-UHFFFAOYSA-N
5
Targets
6
Activities
1
Assay Types
0
PK Parameters
10
Publications
0
Known Names

Molecular Properties

241.2
MW (Da)
1.22
ALogP
3
HBA
2
HBD
70.7
PSA (Ų)
0.67
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C13H11N3O2
MW 241.25
Aromatic Rings 3
Heavy Atoms 18
NP-Likeness -0.70

Activity Summary

Ki 6 meas. best 7.01

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A1
CHEMBL318
Ki 7.01 7.01 97.0 2
Adenosine receptor A2b
CHEMBL255
Ki 6.28 6.28 520.0 1
Adenosine A2 receptor
CHEMBL2094117
Ki 5.7 5.7 2000.0 1
Adenosine receptor A2a
CHEMBL302
Ki 5.7 5.7 2000.0 1
Adenosine receptor A3
CHEMBL256
Ki 5.68 5.68 2098.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
8182711 10.1021/jm00036a019 Adenosine receptor A1 1
8182711 10.1021/jm00036a019 Adenosine A2 receptor 1
8182711 10.1021/jm00036a019 Adenosine receptors; A1 & A2 1
11906291 10.1021/jm011049y Adenosine receptor A1 1
11906291 10.1021/jm011049y Adenosine receptor A2a 1
11906291 10.1021/jm011049y Adenosine receptor A2b 1
11906291 10.1021/jm011049y Adenosine receptor A3 1
11906291 10.1021/jm011049y Adenosine receptors; A1 & A2b 1
11906291 10.1021/jm011049y Adenosine A2 receptor 1
11906291 10.1021/jm011049y Adenosine receptors; A2b & A3 1

Data from ChEMBL 36 via Core Engine