Assay Detail
Binding
CHEMBL642179
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Binding affinity for adenosine A2A receptor from rat brain membranes using [3H]CGS-21680
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Effect of trifluoromethyl and other substituents on activity of xanthines at adenosine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 30 | 5.44 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL329369 | — | — | 1 | 7.38 |
| CHEMBL290589 | — | — | 1 | 7.12 |
| CHEMBL158507 | — | — | 1 | 6.85 |
| CHEMBL89383 | — | — | 1 | 6.68 |
| CHEMBL313646 | — | — | 1 | 6.36 |
| CHEMBL424433 | — | — | 1 | 6.21 |
| CHEMBL418333 | — | — | 1 | 6.10 |
| CHEMBL62350 | 8-PHENYL THEOPHYLLINE | — | 1 | 6.01 |
| CHEMBL90989 | — | — | 1 | 5.80 |
| CHEMBL157655 | — | — | 1 | 5.58 |
| CHEMBL313462 | — | — | 1 | 5.55 |
| CHEMBL85185 | — | — | 1 | 5.55 |
| CHEMBL313543 | — | — | 1 | 5.38 |
| CHEMBL8488 | — | — | 1 | 5.24 |
| CHEMBL275084 | ISOBUTYLMETHYLXANTHINE | — | 1 | 5.24 |
| CHEMBL87121 | — | — | 1 | 5.12 |
| CHEMBL89274 | — | — | 1 | 5.11 |
| CHEMBL1355736 | THEOPHYLLINE | 4.0 | 1 | 5.10 |
| CHEMBL415473 | — | — | 1 | 4.96 |
| CHEMBL91786 | — | — | 1 | 4.92 |
| CHEMBL66610 | — | — | 1 | 4.92 |
| CHEMBL327584 | — | — | 1 | 4.92 |
| CHEMBL327466 | — | — | 1 | 4.80 |
| CHEMBL21053 | — | — | 1 | 4.80 |
| CHEMBL92152 | — | — | 1 | 4.72 |
| CHEMBL20993 | — | — | 1 | 4.70 |
| CHEMBL113 | CAFFEINE | 4.0 | 1 | 4.64 |
| CHEMBL88584 | — | — | 1 | 4.57 |
| CHEMBL88329 | — | — | 1 | 4.54 |
| CHEMBL92364 | — | — | 1 | 4.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL329369 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL290589 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL158507 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL89383 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL313646 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL424433 | — | Ki | = | 610.0 | nM | 6.21 |
| CHEMBL418333 | — | Ki | = | 790.0 | nM | 6.10 |
| CHEMBL62350 | 8-PHENYL THEOPHYLLINE | Ki | = | 970.0 | nM | 6.01 |
| CHEMBL90989 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL157655 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL313462 | — | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL85185 | — | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL313543 | — | Ki | = | 4200.0 | nM | 5.38 |
| CHEMBL8488 | — | Ki | = | 5800.0 | nM | 5.24 |
| CHEMBL275084 | ISOBUTYLMETHYLXANTHINE | Ki | = | 5800.0 | nM | 5.24 |
| CHEMBL87121 | — | Ki | = | 7600.0 | nM | 5.12 |
| CHEMBL89274 | — | Ki | = | 7700.0 | nM | 5.11 |
| CHEMBL1355736 | THEOPHYLLINE | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL415473 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL91786 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL66610 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL327584 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL327466 | — | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL21053 | — | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL92152 | — | Ki | = | 19000.0 | nM | 4.72 |
| CHEMBL20993 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL113 | CAFFEINE | Ki | = | 23000.0 | nM | 4.64 |
| CHEMBL88584 | — | Ki | = | 27000.0 | nM | 4.57 |
| CHEMBL88329 | — | Ki | = | 29000.0 | nM | 4.54 |
| CHEMBL92364 | — | Ki | = | 42000.0 | nM | 4.38 |