Assay Detail
Binding
CHEMBL642292
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Binding affinity against alpha-2 adrenergic receptor in rat cerebral cortical membrane, determined using [3H]- yohimbine as the radioligand.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
(8a alpha,12a alpha,13a alpha)-5,8,8a,9,10,11,12,12a,13,13a-decahydro- 3-methoxy-12-(methylsulfonyl)-6H-isoquino[2,1-g][1,6]naphthyridi ne, a potent and highly selective alpha 2-adrenoceptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.23 | 9.45 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279807 | — | — | 1 | 9.45 |
| CHEMBL62912 | — | — | 1 | 9.18 |
| CHEMBL10316 | IDAZOXAN | 3.0 | 1 | 7.96 |
| CHEMBL62833 | — | — | 1 | 6.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279807 | — | Ki | = | 0.3548 | nM | 9.45 |
| CHEMBL62912 | — | Ki | = | 0.6607 | nM | 9.18 |
| CHEMBL10316 | IDAZOXAN | Ki | = | 10.96 | nM | 7.96 |
| CHEMBL62833 | — | Ki | = | 478.63 | nM | 6.32 |