Assay Detail
Binding
CHEMBL642479
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Evaluated for binding affinity against Adenosine A1 receptor
19
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
A steric and electrostatic comparison of three models for the agonist/antagonist binding site on the adenosine A1 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 8.16 | 9.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL268026 | — | — | 1 | 9.29 |
| CHEMBL183 | 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX] | — | 1 | 9.21 |
| CHEMBL11635 | — | — | 1 | 9.20 |
| CHEMBL269218 | — | — | 1 | 9.19 |
| CHEMBL273267 | — | — | 1 | 8.74 |
| CHEMBL160369 | — | — | 1 | 8.70 |
| CHEMBL11220 | — | — | 1 | 8.62 |
| CHEMBL10937 | — | — | 1 | 8.44 |
| CHEMBL347687 | — | — | 1 | 8.34 |
| CHEMBL269633 | — | — | 1 | 8.27 |
| CHEMBL275329 | — | — | 1 | 8.17 |
| CHEMBL157073 | — | — | 2 | 8.16 |
| CHEMBL11439 | — | — | 1 | 8.06 |
| CHEMBL158507 | — | — | 1 | 7.96 |
| CHEMBL160704 | — | — | 1 | 7.41 |
| CHEMBL53737 | — | — | 1 | 7.38 |
| CHEMBL429032 | — | — | 1 | 6.72 |
| CHEMBL156622 | — | — | 1 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL268026 | — | Ki | = | 0.5129 | nM | 9.29 |
| CHEMBL183 | 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX] | Ki | = | 0.6166 | nM | 9.21 |
| CHEMBL11635 | — | Ki | = | 0.631 | nM | 9.20 |
| CHEMBL269218 | — | Ki | = | 0.6457 | nM | 9.19 |
| CHEMBL273267 | — | Ki | = | 1.82 | nM | 8.74 |
| CHEMBL160369 | — | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL11220 | — | Ki | = | 2.399 | nM | 8.62 |
| CHEMBL10937 | — | Ki | = | 3.631 | nM | 8.44 |
| CHEMBL347687 | — | Ki | = | 4.571 | nM | 8.34 |
| CHEMBL269633 | — | Ki | = | 5.37 | nM | 8.27 |
| CHEMBL275329 | — | Ki | = | 6.761 | nM | 8.17 |
| CHEMBL157073 | — | Ki | = | 6.918 | nM | 8.16 |
| CHEMBL11439 | — | Ki | = | 8.71 | nM | 8.06 |
| CHEMBL158507 | — | Ki | = | 10.96 | nM | 7.96 |
| CHEMBL160704 | — | Ki | = | 38.9 | nM | 7.41 |
| CHEMBL53737 | — | Ki | = | 41.69 | nM | 7.38 |
| CHEMBL157073 | — | Ki | = | 60.26 | nM | 7.22 |
| CHEMBL429032 | — | Ki | = | 190.55 | nM | 6.72 |
| CHEMBL156622 | — | Ki | = | 891.25 | nM | 6.05 |