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Compound Detail

CHEMBL156622

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CCCn1c(=O)c2nc(Cc3ccccc3)[nH]c2n(CCC)c1=O

Basic Information

ChEMBL ID CHEMBL156622
Phase Preclinical
Structure Type MOL
InChI Key YZLVQSTZDPGPKU-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

326.4
MW (Da)
2.30
ALogP
5
HBA
1
HBD
72.7
PSA (Ų)
0.76
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C18H22N4O2
MW 326.40
Aromatic Rings 3
Heavy Atoms 24
NP-Likeness -0.93

Activity Summary

Ki 1 meas. best 6.05

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A1
CHEMBL318
Ki 6.05 6.05 891.2 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Adenosine receptor A1 Ki = 891.25 nM 6.05 Evaluated for binding affinity against Adenosine A1 receptor 1542091

Literature References

PubMed DOI Target Context # Activities
1542091 10.1021/jm00082a003 Adenosine receptor A1 1

Data from ChEMBL 36 via Core Engine