Assay Detail
Binding
CHEMBL642668
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against Acetylcholinesterase of purified Octopus brain (OB)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Octopus |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and study of thiocarbonate derivatives of choline as potential inhibitors of acetylcholinesterase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.58 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1128 | EDROPHONIUM CHLORIDE | 4.0 | 1 | 6.40 |
| CHEMBL640 | PROCAINAMIDE | 4.0 | 1 | 6.00 |
| CHEMBL103873 | — | — | 1 | 5.52 |
| CHEMBL102226 | — | — | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1128 | EDROPHONIUM CHLORIDE | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL640 | PROCAINAMIDE | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL103873 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL102226 | — | Ki | = | 40000.0 | nM | 4.40 |