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Compound Detail

CHEMBL103873

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CCCCCSC(=O)OCC[N+](C)(C)C.[Cl-]

Basic Information

ChEMBL ID CHEMBL103873
Phase Preclinical
Structure Type MOL
InChI Key QRMYKAASZNXXRJ-UHFFFAOYSA-M
Parent Compound CHEMBL1179902
Active Moiety CHEMBL1179902
2
Targets
6
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

234.4
MW (Da)
2.75
ALogP
3
HBA
0
HBD
26.3
PSA (Ų)
0.38
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C11H24ClNO2S
MW 269.84
Aromatic Rings 0
Heavy Atoms 15
NP-Likeness 0.47

Activity Summary

IC50 3 meas. best 6.1
Ki 3 meas. best 6.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Acetylcholinesterase
CHEMBL220
IC50 6.1 5.2 800.0 2
Acetylcholinesterase
CHEMBL4768
IC50 6.0 6.0 1000.0 1
Acetylcholinesterase
CHEMBL4768
Ki 6.0 6.0 1000.0 1
Acetylcholinesterase
CHEMBL220
Ki 5.7 5.61 2000.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
9301662 10.1021/jm970141k Acetylcholinesterase 6

Data from ChEMBL 36 via Core Engine