Assay Detail
Binding
CHEMBL884109
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Inhibition of Acetylcholinesterase activity from octopus brain
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Octopus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and study of thiocarbonate derivatives of choline as potential inhibitors of acetylcholinesterase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.87 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1128 | EDROPHONIUM CHLORIDE | 4.0 | 1 | 6.30 |
| CHEMBL640 | PROCAINAMIDE | 4.0 | 1 | 6.00 |
| CHEMBL103959 | — | — | 1 | 4.30 |
| CHEMBL322628 | — | — | 1 | 4.30 |
| CHEMBL103873 | — | — | 1 | 4.30 |
| CHEMBL102077 | — | — | 1 | 4.00 |
| CHEMBL102637 | — | — | 1 | - |
| CHEMBL102078 | — | — | 1 | - |
| CHEMBL102226 | — | — | 1 | - |
| CHEMBL104891 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1128 | EDROPHONIUM CHLORIDE | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL640 | PROCAINAMIDE | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL103959 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL322628 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL103873 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL102077 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL102637 | — | IC50 | > | 10000000.0 | nM | - |
| CHEMBL102078 | — | IC50 | = | 1000000.0 | nM | - |
| CHEMBL102226 | — | IC50 | = | 500000.0 | nM | - |
| CHEMBL104891 | — | IC50 | > | 1000000.0 | nM | - |