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Assay Detail

CHEMBL644835

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Acetylcholinesterase from human red blood cells
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Acetylcholinesterase (CHEMBL220)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and study of thiocarbonate derivatives of choline as potential inhibitors of acetylcholinesterase.
Boyle NA, Talesa V, Giovannini E, Rosi G, Norton SJ.
J Med Chem (1997) 40 : 3009 -3013
PubMed 9301662 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 5.03 6.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1128 EDROPHONIUM CHLORIDE 4.0 1 6.70
CHEMBL103873 1 6.10
CHEMBL640 PROCAINAMIDE 4.0 1 6.00
CHEMBL103890 1 4.40
CHEMBL322628 1 4.30
CHEMBL103153 1 4.30
CHEMBL102226 1 4.30
CHEMBL102077 1 4.10
CHEMBL102637 1 -
CHEMBL103959 1 -
CHEMBL102078 1 -
CHEMBL318749 1 -
CHEMBL101482 1 -
CHEMBL104891 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1128 EDROPHONIUM CHLORIDE IC50 = 200.0 nM 6.70
CHEMBL103873 IC50 = 800.0 nM 6.10
CHEMBL640 PROCAINAMIDE IC50 = 1000.0 nM 6.00
CHEMBL103890 IC50 = 40000.0 nM 4.40
CHEMBL322628 IC50 = 50000.0 nM 4.30
CHEMBL103153 IC50 = 50000.0 nM 4.30
CHEMBL102226 IC50 = 50000.0 nM 4.30
CHEMBL102077 IC50 = 80000.0 nM 4.10
CHEMBL102637 IC50 > 10000000.0 nM -
CHEMBL103959 IC50 = 500000.0 nM -
CHEMBL102078 IC50 = 500000.0 nM -
CHEMBL318749 IC50 = 1000000.0 nM -
CHEMBL101482 IC50 = 1000000.0 nM -
CHEMBL104891 IC50 > 5000000.0 nM -