Assay Detail
Binding
CHEMBL642973
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat aldose reductase enzyme.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL2622) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Novel inhibitors of rat lens aldose reductase: N-[[(substituted amino)phenyl]sulfonyl]glycines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.21 | 6.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL37092 | — | — | 1 | 6.39 |
| CHEMBL41232 | — | — | 1 | 6.16 |
| CHEMBL40588 | — | — | 1 | 5.66 |
| CHEMBL417523 | — | — | 1 | 5.58 |
| CHEMBL40666 | — | — | 1 | 5.56 |
| CHEMBL40681 | — | — | 1 | 5.46 |
| CHEMBL39134 | — | — | 1 | 5.38 |
| CHEMBL287999 | — | — | 1 | 5.22 |
| CHEMBL41284 | — | — | 1 | 5.15 |
| CHEMBL41021 | — | — | 1 | 5.15 |
| CHEMBL39090 | — | — | 1 | 5.08 |
| CHEMBL288054 | — | — | 1 | 4.96 |
| CHEMBL40492 | — | — | 1 | 4.94 |
| CHEMBL285053 | — | — | 1 | 4.80 |
| CHEMBL289897 | — | — | 1 | 4.54 |
| CHEMBL38109 | — | — | 1 | 4.42 |
| CHEMBL288659 | — | — | 1 | 4.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL37092 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL41232 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL40588 | — | IC50 | = | 2170.0 | nM | 5.66 |
| CHEMBL417523 | — | IC50 | = | 2640.0 | nM | 5.58 |
| CHEMBL40666 | — | IC50 | = | 2750.0 | nM | 5.56 |
| CHEMBL40681 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL39134 | — | IC50 | = | 4220.0 | nM | 5.38 |
| CHEMBL287999 | — | IC50 | = | 6030.0 | nM | 5.22 |
| CHEMBL41284 | — | IC50 | = | 7040.0 | nM | 5.15 |
| CHEMBL41021 | — | IC50 | = | 7120.0 | nM | 5.15 |
| CHEMBL39090 | — | IC50 | = | 8420.0 | nM | 5.08 |
| CHEMBL288054 | — | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL40492 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL285053 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL289897 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL38109 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL288659 | — | IC50 | = | 78000.0 | nM | 4.11 |