Compound Detail
CHEMBL37092
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Basic Information
| ChEMBL ID | CHEMBL37092 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OOKHBGUVFNXREL-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
334.4
MW (Da)
1.30
ALogP
4
HBA
3
HBD
112.6
PSA (Ų)
0.74
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.39
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Aldo-keto reductase family 1 member B1 CHEMBL2622 | IC50 | 6.39 | 6.225 | 410.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Aldo-keto reductase family 1 member B1 | IC50 | = | 410.0 | nM | 6.39 | Inhibition of rat aldose reductase enzyme. | 3114491 |
| Aldo-keto reductase family 1 member B1 | IC50 | = | 880.0 | nM | 6.06 | Inhibitory concentration against aldose reductase obtained from rat lens | 2491890 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 3114491 | 10.1021/jm00392a012 | Aldo-keto reductase family 1 member B1 | 2 |
| 2491890 | 10.1021/jm00121a027 | Aldo-keto reductase family 1 member B1 | 1 |
Data from ChEMBL 36 via Core Engine