Assay Detail
Functional
CHEMBL643135
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Inhibitory activity as antagonist of AII on guinea pig ileum
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of angiotensin II analogues containing a Val-His replacement, Val psi[CH(CONH2)NH]His.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.79 | 10.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL938 | SARALASIN | 4.0 | 1 | 10.18 |
| CHEMBL404594 | — | — | 1 | 9.68 |
| CHEMBL77838 | — | — | 1 | 9.35 |
| CHEMBL312754 | — | — | 1 | 8.24 |
| CHEMBL2369863 | — | — | 1 | 6.48 |
| CHEMBL309651 | — | — | 1 | - |
| CHEMBL418901 | — | — | 1 | - |
| CHEMBL76890 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL938 | SARALASIN | IC50 | = | 0.066 | nM | 10.18 |
| CHEMBL404594 | — | IC50 | = | 0.21 | nM | 9.68 |
| CHEMBL77838 | — | IC50 | = | 0.45 | nM | 9.35 |
| CHEMBL312754 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL2369863 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL309651 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL418901 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL76890 | — | IC50 | > | 15000.0 | nM | - |