Compound Detail
CHEMBL2369863
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CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)N[C@H](C(N)=O)C(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(C)C)C(=O)O
Basic Information
| ChEMBL ID | CHEMBL2369863 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KVCOJRSWXJONHL-JQCHLDKOSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
1011.2
MW (Da)
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.48
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Angiotensin II receptor CHEMBL2094256 | IC50 | 6.48 | 6.48 | 330.0 | 1 |
| Cavia porcellus CHEMBL369 | IC50 | 6.46 | 6.46 | 345.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Angiotensin II receptor | IC50 | = | 330.0 | nM | 6.48 | Inhibitory activity as antagonist of AII on guinea pig ileum | 1875337 |
| Cavia porcellus | IC50 | = | 345.0 | nM | 6.46 | The compound was tested for its inhibitory activity as antagonist of AI on guine... | 1875337 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 1875337 | 10.1021/jm00112a014 | Angiotensin II receptor | 2 |
| 1875337 | 10.1021/jm00112a014 | Cavia porcellus | 1 |
Data from ChEMBL 36 via Core Engine