Assay Detail
Binding
CHEMBL643229
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscine
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
A convenient synthesis of 2-amino-2-oxazolines and their pharmacological evaluation at cloned human adrenergic receptors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.52 | 8.63 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL75030 | — | — | 1 | 8.63 |
| CHEMBL310335 | — | — | 1 | 8.53 |
| CHEMBL305928 | — | — | 1 | 8.27 |
| CHEMBL134 | CLONIDINE | 4.0 | 1 | 8.10 |
| CHEMBL306377 | — | — | 1 | 7.59 |
| CHEMBL289480 | RILMENIDINE | 4.0 | 1 | 6.74 |
| CHEMBL75201 | — | — | 1 | 4.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL75030 | — | Ki | = | 2.344 | nM | 8.63 |
| CHEMBL310335 | — | Ki | = | 2.951 | nM | 8.53 |
| CHEMBL305928 | — | Ki | = | 5.37 | nM | 8.27 |
| CHEMBL134 | CLONIDINE | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL306377 | — | Ki | = | 25.7 | nM | 7.59 |
| CHEMBL289480 | RILMENIDINE | Ki | = | 181.97 | nM | 6.74 |
| CHEMBL75201 | — | Ki | = | 16595.87 | nM | 4.78 |