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Compound Detail

CHEMBL305928

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C1CCCC(NC2=NCCO2)CC1

Basic Information

ChEMBL ID CHEMBL305928
Phase Preclinical
Structure Type MOL
InChI Key DAIRUBYTBODIKT-UHFFFAOYSA-N
4
Targets
9
Activities
2
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

182.3
MW (Da)
1.68
ALogP
3
HBA
1
HBD
33.6
PSA (Ų)
0.63
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C10H18N2O
MW 182.27
Aromatic Rings 0
Heavy Atoms 13
NP-Likeness -0.26

Activity Summary

Ki 6 meas. best 8.27
EC50 3 meas. best 7.42

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Alpha-2A adrenergic receptor
CHEMBL1867
Ki 8.27 8.27 5.4 1
Alpha-2B adrenergic receptor
CHEMBL1942
Ki 8.01 8.01 9.8 1
Alpha-2C adrenergic receptor
CHEMBL1916
Ki 7.48 7.48 33.1 1
Alpha-2A adrenergic receptor
CHEMBL1867
EC50 7.42 7.42 38.0 1
Alpha-2C adrenergic receptor
CHEMBL1916
EC50 7.11 7.11 77.6 1
Alpha-2B adrenergic receptor
CHEMBL1942
EC50 6.67 6.67 213.8 1
Alpha-1A adrenergic receptor
CHEMBL229
Ki 5.7 5.56 1995.3 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.1016/0960-894X(94)85032-1 Alpha-2A adrenergic receptor 2
- 10.1016/0960-894X(94)85032-1 Alpha-2B adrenergic receptor 2
- 10.1016/0960-894X(94)85032-1 Alpha-2C adrenergic receptor 2
- 10.1016/0960-894X(94)85032-1 Alpha-1A adrenergic receptor 2
- 10.1016/0960-894X(94)85032-1 Alpha-1B adrenergic receptor 1

Data from ChEMBL 36 via Core Engine