Assay Detail
Binding
CHEMBL649246
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Binding affinity towards human Alpha-2C adrenergic receptor by the displacement of [3H]rauwolscine
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
A convenient synthesis of 2-amino-2-oxazolines and their pharmacological evaluation at cloned human adrenergic receptors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.95 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL75030 | — | — | 1 | 7.92 |
| CHEMBL310335 | — | — | 1 | 7.61 |
| CHEMBL305928 | — | — | 1 | 7.48 |
| CHEMBL134 | CLONIDINE | 4.0 | 1 | 7.25 |
| CHEMBL306377 | — | — | 1 | 7.07 |
| CHEMBL289480 | RILMENIDINE | 4.0 | 1 | 6.54 |
| CHEMBL75201 | — | — | 1 | 4.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL75030 | — | Ki | = | 12.02 | nM | 7.92 |
| CHEMBL310335 | — | Ki | = | 24.55 | nM | 7.61 |
| CHEMBL305928 | — | Ki | = | 33.11 | nM | 7.48 |
| CHEMBL134 | CLONIDINE | Ki | = | 56.23 | nM | 7.25 |
| CHEMBL306377 | — | Ki | = | 85.11 | nM | 7.07 |
| CHEMBL289480 | RILMENIDINE | Ki | = | 288.4 | nM | 6.54 |
| CHEMBL75201 | — | Ki | = | 16595.87 | nM | 4.78 |