Assay Detail
Functional
CHEMBL649236
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Agonistic activity towards human Alpha-2C adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
A convenient synthesis of 2-amino-2-oxazolines and their pharmacological evaluation at cloned human adrenergic receptors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 7.63 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL75030 | — | — | 1 | 8.66 |
| CHEMBL310335 | — | — | 1 | 8.39 |
| CHEMBL306377 | — | — | 1 | 7.61 |
| CHEMBL134 | CLONIDINE | 4.0 | 1 | 7.26 |
| CHEMBL305928 | — | — | 1 | 7.11 |
| CHEMBL289480 | RILMENIDINE | 4.0 | 1 | 6.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL75030 | — | EC50 | = | 2.188 | nM | 8.66 |
| CHEMBL310335 | — | EC50 | = | 4.074 | nM | 8.39 |
| CHEMBL306377 | — | EC50 | = | 24.55 | nM | 7.61 |
| CHEMBL134 | CLONIDINE | EC50 | = | 54.95 | nM | 7.26 |
| CHEMBL305928 | — | EC50 | = | 77.62 | nM | 7.11 |
| CHEMBL289480 | RILMENIDINE | EC50 | = | 190.55 | nM | 6.72 |