Assay Detail
Functional
CHEMBL643580
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Agonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
A convenient synthesis of 2-amino-2-oxazolines and their pharmacological evaluation at cloned human adrenergic receptors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 7.74 | 8.93 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL75030 | — | — | 1 | 8.93 |
| CHEMBL310335 | — | — | 1 | 8.79 |
| CHEMBL134 | CLONIDINE | 4.0 | 1 | 8.09 |
| CHEMBL305928 | — | — | 1 | 7.42 |
| CHEMBL306377 | — | — | 1 | 6.64 |
| CHEMBL289480 | RILMENIDINE | 4.0 | 1 | 6.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL75030 | — | EC50 | = | 1.175 | nM | 8.93 |
| CHEMBL310335 | — | EC50 | = | 1.622 | nM | 8.79 |
| CHEMBL134 | CLONIDINE | EC50 | = | 8.128 | nM | 8.09 |
| CHEMBL305928 | — | EC50 | = | 38.02 | nM | 7.42 |
| CHEMBL306377 | — | EC50 | = | 229.09 | nM | 6.64 |
| CHEMBL289480 | RILMENIDINE | EC50 | = | 275.42 | nM | 6.56 |