Assay Detail
Binding
CHEMBL643405
Review assay metadata, readout intent, target linkage, and publication context from the same page.
in vitro alpha-1 adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Alpha(2) adrenoceptor agonists as potential analgesic agents. 2. Discovery of 4-(4-imidazo)-1,3-dimethyl-6,7-dihydro-thianaphthene as a high-affinity ligand for the alpha(2D) adrenergic receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.87 | 7.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL30739 | — | — | 1 | 7.32 |
| CHEMBL286269 | — | — | 1 | 7.04 |
| CHEMBL284213 | — | — | 1 | 6.96 |
| CHEMBL284795 | — | — | 1 | 6.96 |
| CHEMBL134 | CLONIDINE | 4.0 | 1 | 6.94 |
| CHEMBL30534 | — | — | 1 | 6.46 |
| CHEMBL30955 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL30739 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL286269 | — | Ki | = | 91.0 | nM | 7.04 |
| CHEMBL284213 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL284795 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL134 | CLONIDINE | Ki | = | 116.0 | nM | 6.94 |
| CHEMBL30534 | — | Ki | = | 343.0 | nM | 6.46 |
| CHEMBL30955 | — | Ki | = | 399.0 | nM | 6.40 |