Assay Detail
Binding
CHEMBL643571
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Tested for inhibition of rat PC12 adenylate cyclase stimulation by using NECA as a radioligand
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | PC-12 |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
N6,9-disubstituted adenines: potent, selective antagonists at the A1 adenosine receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 4.61 | 5.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96014 | — | — | 1 | 5.00 |
| CHEMBL95936 | — | — | 1 | 4.96 |
| CHEMBL95897 | — | — | 1 | 4.92 |
| CHEMBL319010 | — | — | 1 | 4.33 |
| CHEMBL96015 | — | — | 1 | 4.30 |
| CHEMBL62756 | — | — | 1 | 4.13 |
| CHEMBL321749 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96014 | — | Ki | = | 9900.0 | nM | 5.00 |
| CHEMBL95936 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL95897 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL319010 | — | Ki | = | 47000.0 | nM | 4.33 |
| CHEMBL96015 | — | Ki | = | 50000.0 | nM | 4.30 |
| CHEMBL62756 | — | Ki | = | 74000.0 | nM | 4.13 |
| CHEMBL321749 | — | Ki | = | 107000.0 | nM | - |