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Compound Detail

CHEMBL321749

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Cn1cnc2c(Nc3ccccc3)ncnc21

Basic Information

ChEMBL ID CHEMBL321749
Phase Preclinical
Structure Type MOL
InChI Key STTSYIXNIOADQX-UHFFFAOYSA-N
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
18
Publications
0
Known Names

Molecular Properties

225.2
MW (Da)
2.11
ALogP
5
HBA
1
HBD
55.6
PSA (Ų)
0.73
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C12H11N5
MW 225.25
Aromatic Rings 3
Heavy Atoms 17
NP-Likeness -1.11

Activity Summary

Ki 3 meas. best 5.16

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A1
CHEMBL318
Ki 5.16 5.16 6900.0 1
Adenosine A2 receptor
CHEMBL2094117
Ki 4.17 4.17 68000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
1895305 10.1021/jm00113a029 Adenosine A2 receptor 2
15689155 10.1021/jm0408767 Mitogen-activated protein kinase 1 1
1895305 10.1021/jm00113a029 Adenosine receptor A1 1
15689155 10.1021/jm0408767 Mitogen-activated protein kinase 3 1
15689155 10.1021/jm0408767 Tyrosine-protein kinase Lck 1
15689155 10.1021/jm0408767 Mitogen-activated protein kinase 10 1
15689155 10.1021/jm0408767 Mitogen-activated protein kinase 9 1
15689155 10.1021/jm0408767 Mitogen-activated protein kinase 8 1
15689155 10.1021/jm0408767 Glycogen synthase kinase-3 beta 1
15689155 10.1021/jm0408767 Ca2+/calmodulin-dependent protein kinase II (CaM kinase II) 1
15689155 10.1021/jm0408767 Mitogen-activated protein kinase 14 1
15689155 10.1021/jm0408767 Rho-associated protein kinase 1 1
15689155 10.1021/jm0408767 Protein kinase C alpha type 1
15689155 10.1021/jm0408767 RAC-alpha serine/threonine-protein kinase 1
15689155 10.1021/jm0408767 cAMP-dependent protein kinase (PKA) 1
15689155 10.1021/jm0408767 Dual specificity mitogen-activated protein kinase kinase 1 1
15689155 10.1021/jm0408767 RAF proto-oncogene serine/threonine-protein kinase 1
1895305 10.1021/jm00113a029 Adenosine receptors; A1 & A2 1

Data from ChEMBL 36 via Core Engine