Assay Detail
Binding
CHEMBL648805
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Binding affinity against adenosine A2 receptor in rat striatum by using [3H]NECA as a radioligand
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
N6,9-disubstituted adenines: potent, selective antagonists at the A1 adenosine receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 4.66 | 5.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL318453 | — | — | 1 | 5.17 |
| CHEMBL294590 | — | — | 1 | 5.09 |
| CHEMBL304009 | — | — | 1 | 5.06 |
| CHEMBL88788 | — | — | 1 | 5.03 |
| CHEMBL317398 | — | — | 1 | 4.96 |
| CHEMBL321753 | — | — | 1 | 4.96 |
| CHEMBL48278 | — | — | 1 | 4.96 |
| CHEMBL95332 | — | — | 1 | 4.89 |
| CHEMBL65976 | — | — | 1 | 4.82 |
| CHEMBL95936 | — | — | 1 | 4.82 |
| CHEMBL301574 | — | — | 1 | 4.77 |
| CHEMBL96014 | — | — | 1 | 4.75 |
| CHEMBL95617 | — | — | 1 | 4.72 |
| CHEMBL64239 | — | — | 1 | 4.64 |
| CHEMBL98779 | — | — | 1 | 4.51 |
| CHEMBL62756 | — | — | 1 | 4.42 |
| CHEMBL95913 | — | — | 1 | 4.41 |
| CHEMBL95897 | — | — | 1 | 4.34 |
| CHEMBL320370 | — | — | 1 | 4.33 |
| CHEMBL1202925 | — | — | 1 | 4.26 |
| CHEMBL321749 | — | — | 1 | 4.17 |
| CHEMBL319010 | — | — | 1 | 4.10 |
| CHEMBL1202924 | — | — | 1 | 4.08 |
| CHEMBL96015 | — | — | 1 | - |
| CHEMBL99407 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL318453 | — | Ki | = | 6800.0 | nM | 5.17 |
| CHEMBL294590 | — | Ki | = | 8200.0 | nM | 5.09 |
| CHEMBL304009 | — | Ki | = | 8800.0 | nM | 5.06 |
| CHEMBL88788 | — | Ki | = | 9300.0 | nM | 5.03 |
| CHEMBL317398 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL321753 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL48278 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL95332 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL65976 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL95936 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL301574 | — | Ki | = | 17000.0 | nM | 4.77 |
| CHEMBL96014 | — | Ki | = | 18000.0 | nM | 4.75 |
| CHEMBL95617 | — | Ki | = | 19000.0 | nM | 4.72 |
| CHEMBL64239 | — | Ki | = | 23000.0 | nM | 4.64 |
| CHEMBL98779 | — | Ki | = | 31000.0 | nM | 4.51 |
| CHEMBL62756 | — | Ki | = | 38000.0 | nM | 4.42 |
| CHEMBL95913 | — | Ki | = | 39000.0 | nM | 4.41 |
| CHEMBL95897 | — | Ki | = | 46000.0 | nM | 4.34 |
| CHEMBL320370 | — | Ki | = | 47000.0 | nM | 4.33 |
| CHEMBL1202925 | — | Ki | = | 55000.0 | nM | 4.26 |
| CHEMBL321749 | — | Ki | = | 68000.0 | nM | 4.17 |
| CHEMBL319010 | — | Ki | = | 79000.0 | nM | 4.10 |
| CHEMBL1202924 | — | Ki | = | 84000.0 | nM | 4.08 |
| CHEMBL96015 | — | Ki | = | 111000.0 | nM | - |
| CHEMBL99407 | — | Ki | = | 12000000.0 | nM | - |