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Compound Detail

CHEMBL301574

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CCn1cnc2c(NC3CCCC3)ncnc21

Basic Information

ChEMBL ID CHEMBL301574
Phase Preclinical
Structure Type MOL
InChI Key CDVHQRUOORNLKE-UHFFFAOYSA-N
3
Targets
5
Activities
1
Assay Types
0
PK Parameters
10
Publications
0
Known Names

Molecular Properties

231.3
MW (Da)
2.20
ALogP
5
HBA
1
HBD
55.6
PSA (Ų)
0.88
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C12H17N5
MW 231.30
Aromatic Rings 2
Heavy Atoms 17
NP-Likeness -1.14

Activity Summary

Ki 5 meas. best 6.36

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A1
CHEMBL318
Ki 6.36 6.36 440.0 2
Adenosine A2 receptor
CHEMBL2094117
Ki 4.99 4.88 10300.0 2
Adenosine receptor A2a
CHEMBL302
Ki 4.77 4.77 17000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
1895305 10.1021/jm00113a029 Adenosine A2 receptor 2
19731917 10.1021/jm9006356 Unchecked 2
1895305 10.1021/jm00113a029 Adenosine receptor A1 1
1895305 10.1021/jm00113a029 ADMET 1
1895305 10.1021/jm00113a029 Adenosine receptors; A1 & A2 1
7752196 10.1021/jm00010a017 Adenosine receptor A1 1
7752196 10.1021/jm00010a017 Adenosine receptor A2a 1
7752196 10.1021/jm00010a017 Adenosine receptor A3 1
7752196 10.1021/jm00010a017 Adenosine receptors; A1 & A3 1
7752196 10.1021/jm00010a017 Adenosine receptor A2a and A3 1

Data from ChEMBL 36 via Core Engine