Assay Detail
Binding
CHEMBL643610
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Displacement of [3H]prazosin from Alpha-1 adrenergic receptor of whole rat brain membranes
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Selective, centrally acting serotonin 5-HT2 antagonists. 1. 2- and 6-substituted 1-phenyl-3-(4-piperidinyl)-1H-indoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 7.35 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL344276 | — | — | 1 | 8.66 |
| CHEMBL12780 | — | — | 1 | 8.52 |
| CHEMBL12713 | SERTINDOLE | 4.0 | 1 | 8.47 |
| CHEMBL423009 | — | — | 1 | 8.02 |
| CHEMBL359046 | — | — | 1 | 7.89 |
| CHEMBL144457 | — | — | 1 | 7.80 |
| CHEMBL342104 | — | — | 1 | 7.66 |
| CHEMBL422840 | — | — | 1 | 7.64 |
| CHEMBL144086 | — | — | 1 | 7.62 |
| CHEMBL144252 | — | — | 1 | 7.58 |
| CHEMBL145460 | — | — | 1 | 7.57 |
| CHEMBL422480 | — | — | 1 | 7.54 |
| CHEMBL341669 | — | — | 1 | 7.48 |
| CHEMBL357178 | — | — | 1 | 7.47 |
| CHEMBL145763 | — | — | 1 | 7.41 |
| CHEMBL331545 | — | — | 1 | 7.16 |
| CHEMBL144951 | — | — | 1 | 7.12 |
| CHEMBL423024 | — | — | 1 | 7.12 |
| CHEMBL144325 | — | — | 1 | 7.07 |
| CHEMBL144184 | — | — | 1 | 7.04 |
| CHEMBL145706 | — | — | 1 | 6.92 |
| CHEMBL343899 | — | — | 1 | 6.92 |
| CHEMBL143782 | — | — | 1 | 6.60 |
| CHEMBL357186 | — | — | 1 | 6.43 |
| CHEMBL144165 | — | — | 1 | 6.35 |
| CHEMBL358994 | — | — | 1 | 6.17 |
| CHEMBL142908 | — | — | 1 | 6.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL344276 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL12780 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL12713 | SERTINDOLE | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL423009 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL359046 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL144457 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL342104 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL422840 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL144086 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL144252 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL145460 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL422480 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL341669 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL357178 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL145763 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL331545 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL144951 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL423024 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL144325 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL144184 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL145706 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL343899 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL143782 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL357186 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL144165 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL358994 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL142908 | — | IC50 | = | 730.0 | nM | 6.14 |