Compound Detail
CHEMBL144951
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Basic Information
| ChEMBL ID | CHEMBL144951 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VINVVWQQTYVRCW-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
436.6
MW (Da)
4.97
ALogP
3
HBA
2
HBD
49.3
PSA (Ų)
0.57
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.74
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serotonin 2 (5-HT2) receptor CHEMBL2093870 | IC50 | 8.74 | 8.74 | 1.8 | 1 |
| Adrenergic receptor alpha-1 CHEMBL1907610 | IC50 | 7.12 | 7.12 | 76.0 | 1 |
| D(2) dopamine receptor CHEMBL339 | IC50 | 6.52 | 6.52 | 300.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serotonin 2 (5-HT2) receptor | IC50 | = | 1.8 | nM | 8.74 | Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor from rat cort... | 1336053 |
| Adrenergic receptor alpha-1 | IC50 | = | 76.0 | nM | 7.12 | Displacement of [3H]prazosin from Alpha-1 adrenergic receptor of whole rat brain... | 1336053 |
| D(2) dopamine receptor | IC50 | = | 300.0 | nM | 6.52 | Displacement of [3H]-spiperone from Dopamine receptor D2 from rat striatal membr... | 1336053 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 1336053 | 10.1021/jm00104a006 | Serotonin 2 (5-HT2) receptor | 1 |
| 1336053 | 10.1021/jm00104a006 | D(2) dopamine receptor | 1 |
| 1336053 | 10.1021/jm00104a006 | Adrenergic receptor alpha-1 | 1 |
Data from ChEMBL 36 via Core Engine