Assay Detail
Binding
CHEMBL671109
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Displacement of [3H]-spiperone from Dopamine receptor D2 from rat striatal membranes
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Selective, centrally acting serotonin 5-HT2 antagonists. 1. 2- and 6-substituted 1-phenyl-3-(4-piperidinyl)-1H-indoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.73 | 8.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL344276 | — | — | 1 | 8.44 |
| CHEMBL12713 | SERTINDOLE | 4.0 | 1 | 8.39 |
| CHEMBL12780 | — | — | 1 | 7.75 |
| CHEMBL422480 | — | — | 1 | 7.57 |
| CHEMBL359046 | — | — | 1 | 7.55 |
| CHEMBL342104 | — | — | 1 | 7.42 |
| CHEMBL423009 | — | — | 1 | 7.25 |
| CHEMBL144252 | — | — | 1 | 7.13 |
| CHEMBL144457 | — | — | 1 | 7.09 |
| CHEMBL422840 | — | — | 1 | 6.80 |
| CHEMBL144325 | — | — | 1 | 6.72 |
| CHEMBL357178 | — | — | 1 | 6.70 |
| CHEMBL341669 | — | — | 1 | 6.58 |
| CHEMBL144086 | — | — | 1 | 6.57 |
| CHEMBL144184 | — | — | 1 | 6.55 |
| CHEMBL145763 | — | — | 1 | 6.54 |
| CHEMBL144951 | — | — | 1 | 6.52 |
| CHEMBL145706 | — | — | 1 | 6.52 |
| CHEMBL423024 | — | — | 1 | 6.42 |
| CHEMBL343899 | — | — | 1 | 6.30 |
| CHEMBL145460 | — | — | 1 | 6.23 |
| CHEMBL144165 | — | — | 1 | 6.21 |
| CHEMBL357186 | — | — | 1 | 6.14 |
| CHEMBL142908 | — | — | 1 | 5.70 |
| CHEMBL143782 | — | — | 1 | 5.58 |
| CHEMBL358994 | — | — | 1 | 5.50 |
| CHEMBL356320 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL344276 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL12713 | SERTINDOLE | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL12780 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL422480 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL359046 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL342104 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL423009 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL144252 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL144457 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL422840 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL144325 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL357178 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL341669 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL144086 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL144184 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL145763 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL144951 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL145706 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL423024 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL343899 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL145460 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL144165 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL357186 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL142908 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL143782 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL358994 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL356320 | — | IC50 | = | 3200.0 | nM | 5.50 |