Assay Detail
Binding
CHEMBL643708
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Inhibition of [3H]ZM-241385 binding to adenosine A2A receptor(AR).
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Fluorosulfonyl-substituted xanthines as selective irreversible antagonists for the A(1)-adenosine receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.95 | 9.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL144360 | — | — | 1 | 9.38 |
| CHEMBL327708 | — | — | 1 | 8.92 |
| CHEMBL321218 | — | — | 1 | 8.55 |
| CHEMBL359066 | — | — | 1 | - |
| CHEMBL147156 | — | — | 1 | - |
| CHEMBL148098 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL144360 | — | IC50 | = | 0.42 | nM | 9.38 |
| CHEMBL327708 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL321218 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL359066 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL147156 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL148098 | — | IC50 | > | 10.0 | nM | - |