Assay Detail
Binding
CHEMBL643957
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogenates by [3H]clonidine displacement.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and hypoglycemic activity of substituted 8-(1-piperazinyl)imidazo[1,2-a]pyrazines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 6.46 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL331036 | — | — | 1 | 7.82 |
| CHEMBL544354 | — | — | 1 | 7.29 |
| CHEMBL330994 | — | — | 1 | 7.09 |
| CHEMBL541088 | — | — | 1 | 6.85 |
| CHEMBL123566 | — | — | 1 | 6.74 |
| CHEMBL545289 | — | — | 1 | 6.72 |
| CHEMBL555637 | — | — | 1 | 6.62 |
| CHEMBL538788 | — | — | 1 | 6.62 |
| CHEMBL338704 | — | — | 1 | 6.57 |
| CHEMBL543653 | — | — | 1 | 6.47 |
| CHEMBL555391 | — | — | 1 | 6.43 |
| CHEMBL545293 | — | — | 1 | 6.32 |
| CHEMBL538537 | — | — | 1 | 6.28 |
| CHEMBL554785 | — | — | 1 | 6.21 |
| CHEMBL340358 | — | — | 1 | 6.06 |
| CHEMBL127303 | — | — | 1 | 5.99 |
| CHEMBL127318 | — | — | 1 | 5.87 |
| CHEMBL126394 | — | — | 1 | 5.80 |
| CHEMBL124926 | — | — | 1 | 4.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL331036 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL544354 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL330994 | — | Ki | = | 81.0 | nM | 7.09 |
| CHEMBL541088 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL123566 | — | Ki | = | 182.0 | nM | 6.74 |
| CHEMBL545289 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL555637 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL538788 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL338704 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL543653 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL555391 | — | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL545293 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL538537 | — | Ki | = | 530.0 | nM | 6.28 |
| CHEMBL554785 | — | Ki | = | 620.0 | nM | 6.21 |
| CHEMBL340358 | — | Ki | = | 870.0 | nM | 6.06 |
| CHEMBL127303 | — | Ki | = | 1020.0 | nM | 5.99 |
| CHEMBL127318 | — | Ki | = | 1350.0 | nM | 5.87 |
| CHEMBL126394 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL124926 | — | Ki | = | 11860.0 | nM | 4.93 |