Compound Detail
CHEMBL126394
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Basic Information
| ChEMBL ID | CHEMBL126394 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DDLRSDUTHPWRGU-BTJKTKAUSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
363.4
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 5.8
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Alpha-2A adrenergic receptor CHEMBL4744 | Ki | 5.8 | 5.8 | 1600.0 | 1 |
| Beta-1 adrenergic receptor CHEMBL5471 | Ki | 4.99 | 4.99 | 10310.0 | 1 |
| Beta-2 adrenergic receptor CHEMBL5414 | Ki | 4.75 | 4.75 | 17700.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Alpha-2A adrenergic receptor | Ki | = | 1600.0 | nM | 5.8 | Binding affinity at Alpha-2 adrenergic receptor in calf cerebral cortex homogena... | 1359141 |
| Beta-1 adrenergic receptor | Ki | = | 10310.0 | nM | 4.99 | Binding affinity at Beta-1 adrenergic receptor in guinea pigs by [125I]CYP displ... | 1359141 |
| Beta-2 adrenergic receptor | Ki | = | 17700.0 | nM | 4.75 | Binding affinity against Beta-2 adrenergic receptor was measured using [125I]CYP... | 1359141 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 1359141 | 10.1021/jm00099a012 | Alpha-1A adrenergic receptor | 1 |
| 1359141 | 10.1021/jm00099a012 | Alpha-2A adrenergic receptor | 1 |
| 1359141 | 10.1021/jm00099a012 | Beta-1 adrenergic receptor | 1 |
| 1359141 | 10.1021/jm00099a012 | Beta-2 adrenergic receptor | 1 |
| 1359141 | 10.1021/jm00099a012 | Mus musculus | 1 |
Data from ChEMBL 36 via Core Engine