Assay Detail
Binding
CHEMBL644119
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In vitro inhibition of human recombinant AChE.
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Quaternary salts of E2020 analogues as acetylcholinesterase inhibitors for the reversal of neuromuscular block.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.34 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL87273 | — | — | 1 | 8.10 |
| CHEMBL87344 | — | — | 1 | 7.77 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 7.75 |
| CHEMBL87014 | — | — | 1 | 7.66 |
| CHEMBL314989 | — | — | 1 | 7.60 |
| CHEMBL87823 | — | — | 1 | 7.30 |
| CHEMBL86835 | — | — | 1 | 7.18 |
| CHEMBL86031 | — | — | 1 | 7.00 |
| CHEMBL432376 | — | — | 1 | 6.92 |
| CHEMBL313582 | — | — | 1 | 6.86 |
| CHEMBL313231 | — | — | 1 | 6.62 |
| CHEMBL659 | GALANTAMINE | 4.0 | 1 | - |
| CHEMBL315385 | — | — | 1 | - |
| CHEMBL85404 | — | — | 1 | - |
| CHEMBL611808 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL87273 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL87344 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL87014 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL314989 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL87823 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL86835 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL86031 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL432376 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL313582 | — | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL313231 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL659 | GALANTAMINE | IC50 | ~ | 500.0 | nM | - |
| CHEMBL315385 | — | IC50 | < | 500.0 | nM | - |
| CHEMBL85404 | — | IC50 | ~ | 500.0 | nM | - |
| CHEMBL611808 | — | IC50 | > | 100000.0 | nM | - |