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Compound Detail

CHEMBL85404

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COc1ccc2c3c1OC1C[C@@H](O)C=C[C@@]31CC[N+](C)(C)C2

Basic Information

ChEMBL ID CHEMBL85404
Phase Preclinical
Structure Type MOL
InChI Key FESJTOGKKMDYHG-LWSHRDBSSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

302.4
MW (Da)
1.99
ALogP
3
HBA
1
HBD
38.7
PSA (Ų)
0.64
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C18H24NO3+
MW 302.39
Aromatic Rings 1
Heavy Atoms 22
NP-Likeness 2.21

Activity Summary

EC50 1 meas. best 6.2

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Acetylcholinesterase
CHEMBL220
EC50 6.2 6.2 630.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Acetylcholinesterase EC50 = 630.0 nM 6.2 In vitro reversal of vecuronium-induced neuromuscular block in guinea pig hemi-d... 12182861

Literature References

PubMed DOI Target Context # Activities
12182861 10.1016/s0960-894x(02)00482-1 Felis catus 5
12182861 10.1016/s0960-894x(02)00482-1 Acetylcholinesterase 2

Data from ChEMBL 36 via Core Engine