Assay Detail
Functional
CHEMBL684541
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In vitro reversal of vecuronium-induced neuromuscular block in guinea pig hemi-diaphragm.
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Quaternary salts of E2020 analogues as acetylcholinesterase inhibitors for the reversal of neuromuscular block.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 22 | 6.41 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL86863 | — | — | 1 | 7.92 |
| CHEMBL87273 | — | — | 1 | 7.72 |
| CHEMBL245079 | HUPERZINE B | — | 1 | 7.72 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 7.37 |
| CHEMBL87344 | — | — | 1 | 7.05 |
| CHEMBL314989 | — | — | 1 | 7.00 |
| CHEMBL87632 | — | — | 1 | 7.00 |
| CHEMBL315385 | — | — | 1 | 6.48 |
| CHEMBL87014 | — | — | 1 | 6.37 |
| CHEMBL87823 | — | — | 1 | 6.28 |
| CHEMBL85404 | — | — | 1 | 6.20 |
| CHEMBL87623 | — | — | 1 | 6.05 |
| CHEMBL659 | GALANTAMINE | 4.0 | 1 | 5.96 |
| CHEMBL75013 | ZANAPEZIL | 2.0 | 1 | 5.94 |
| CHEMBL87883 | — | — | 1 | 5.84 |
| CHEMBL432376 | — | — | 1 | 5.80 |
| CHEMBL313231 | — | — | 1 | 5.77 |
| CHEMBL87955 | — | — | 1 | 5.73 |
| CHEMBL313778 | — | — | 1 | 5.57 |
| CHEMBL313234 | — | — | 1 | 4.36 |
| CHEMBL86031 | — | — | 1 | - |
| CHEMBL611808 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL86863 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL87273 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL245079 | HUPERZINE B | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL502 | DONEPEZIL | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL87344 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL314989 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL87632 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL315385 | — | EC50 | = | 331.0 | nM | 6.48 |
| CHEMBL87014 | — | EC50 | = | 430.0 | nM | 6.37 |
| CHEMBL87823 | — | EC50 | = | 530.0 | nM | 6.28 |
| CHEMBL85404 | — | EC50 | = | 630.0 | nM | 6.20 |
| CHEMBL87623 | — | EC50 | = | 890.0 | nM | 6.05 |
| CHEMBL659 | GALANTAMINE | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL75013 | ZANAPEZIL | EC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL87883 | — | EC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL432376 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL313231 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL87955 | — | EC50 | = | 1880.0 | nM | 5.73 |
| CHEMBL313778 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL313234 | — | EC50 | = | 43500.0 | nM | 4.36 |
| CHEMBL86031 | — | EC50 | > | 3000.0 | nM | - |
| CHEMBL611808 | — | EC50 | > | 10000.0 | nM | - |