Assay Detail
Functional
CHEMBL644563
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Antagonist potency towards alpha-1 adrenergic receptor in the rat electrically stimulated vas deferens with reference to phenylephrine
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Vas deferens |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Effect of methoxy substitution on the adrenergic activity of three structurally related alpha 2-adrenoreceptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 6.96 | 7.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10332 | — | — | 1 | 7.43 |
| CHEMBL31836 | PIPEROXAN | 2.0 | 1 | 7.16 |
| CHEMBL10316 | IDAZOXAN | 3.0 | 1 | 6.30 |
| CHEMBL52429 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10332 | — | Kd | = | 37.15 | nM | 7.43 |
| CHEMBL31836 | PIPEROXAN | Kd | = | 69.18 | nM | 7.16 |
| CHEMBL10316 | IDAZOXAN | Kd | = | 501.19 | nM | 6.30 |
| CHEMBL52429 | — | Kd | > | 33113.11 | nM | - |