Assay Detail
Binding
CHEMBL644576
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Compound is evaluated for the inhibition of porcine plasma Angiotensin I converting enzyme
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Tissue | Plasma |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of a ketomethylene analogue of a tripeptide inhibitor of angiotensin converting enzyme.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.78 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL435360 | — | — | 1 | 7.16 |
| CHEMBL408983 | TEPROTIDE | 2.0 | 1 | 6.66 |
| CHEMBL1560 | CAPTOPRIL | 4.0 | 1 | 6.52 |
| CHEMBL264538 | — | — | 1 | 6.14 |
| CHEMBL28361 | — | — | 1 | 5.85 |
| CHEMBL32032 | — | — | 1 | 5.03 |
| CHEMBL27560 | — | — | 1 | 4.70 |
| CHEMBL29031 | — | — | 1 | 4.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL435360 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL408983 | TEPROTIDE | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL1560 | CAPTOPRIL | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL264538 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL28361 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL32032 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL27560 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL29031 | — | IC50 | = | 67000.0 | nM | 4.17 |