Assay Detail
Binding
CHEMBL644579
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Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Type-1 angiotensin II receptor B (CHEMBL263) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Nonpeptide angiotensin II antagonists: N-phenyl-1H-pyrrole derivatives are angiotensin II receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.54 | 8.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL85595 | — | — | 1 | 8.19 |
| CHEMBL12810 | — | — | 1 | 7.48 |
| CHEMBL276150 | — | — | 1 | 7.28 |
| CHEMBL12693 | — | — | 1 | 7.14 |
| CHEMBL12451 | — | — | 1 | 7.06 |
| CHEMBL12766 | — | — | 1 | 7.02 |
| CHEMBL12737 | — | — | 1 | 6.57 |
| CHEMBL276381 | — | — | 1 | 6.54 |
| CHEMBL12548 | — | — | 1 | 6.32 |
| CHEMBL267547 | — | — | 1 | 5.96 |
| CHEMBL13071 | — | — | 1 | 5.70 |
| CHEMBL430279 | — | — | 1 | 5.38 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 4.44 |
| CHEMBL12190 | — | — | 1 | - |
| CHEMBL274447 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL85595 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL12810 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL276150 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL12693 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL12451 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL12766 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL12737 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL276381 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL12548 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL267547 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL13071 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL430279 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL191 | LOSARTAN | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL12190 | — | IC50 | = | 870000.0 | nM | - |
| CHEMBL274447 | — | IC50 | = | 170000.0 | nM | - |