Compound Detail
CHEMBL430279
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Basic Information
| ChEMBL ID | CHEMBL430279 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NQOOFKORTOTUKO-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
388.9
MW (Da)
4.38
ALogP
5
HBA
2
HBD
88.5
PSA (Ų)
0.60
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.38
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Angiotensin II receptor CHEMBL2094112 | IC50 | 5.38 | 5.38 | 4200.0 | 1 |
| Type-1 angiotensin II receptor B CHEMBL263 | IC50 | 5.38 | 5.38 | 4200.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Type-1 angiotensin II receptor B | IC50 | = | 4200.0 | nM | 5.38 | Activity against high affinity Angiotensin II receptor, type 1 was measured from... | 8421274 |
| Angiotensin II receptor | IC50 | = | 4200.0 | nM | 5.38 | Inhibition of radioligand [3H]angiotensin II binding to angiotensin II receptor ... | 1875348 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8421274 | 10.1021/jm00053a013 | Type-1 angiotensin II receptor B | 1 |
| 1875348 | 10.1021/jm00112a031 | Angiotensin II receptor | 1 |
Data from ChEMBL 36 via Core Engine