Assay Detail
Binding
CHEMBL644626
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Inhibition of human acetylcholinesterase from erythrocytes (RBC)
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Total syntheses and anticholinesterase activities of (3aS)-N(8)-norphysostigmine, (3aS)-N(8)-norphenserine, their antipodal isomers, and other N(8)-substituted analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.26 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54727 | — | — | 1 | 7.62 |
| CHEMBL94 | PHYSOSTIGMINE | 3.0 | 1 | 7.55 |
| CHEMBL418917 | — | — | 1 | 7.39 |
| CHEMBL431784 | — | — | 1 | 7.25 |
| CHEMBL80221 | — | — | 1 | 6.79 |
| CHEMBL319541 | — | — | 1 | 6.61 |
| CHEMBL99581 | — | — | 1 | 6.41 |
| CHEMBL100366 | — | — | 1 | 6.11 |
| CHEMBL99414 | — | — | 1 | 5.66 |
| CHEMBL317162 | — | — | 1 | 5.55 |
| CHEMBL75919 | — | — | 1 | 5.46 |
| CHEMBL99284 | — | — | 1 | 5.25 |
| CHEMBL76640 | (+)-PHYSOSTIGMINE | — | 1 | 5.00 |
| CHEMBL99655 | — | — | 1 | 4.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54727 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL94 | PHYSOSTIGMINE | IC50 | = | 27.9 | nM | 7.55 |
| CHEMBL418917 | — | IC50 | = | 40.8 | nM | 7.39 |
| CHEMBL431784 | — | IC50 | = | 56.7 | nM | 7.25 |
| CHEMBL80221 | — | IC50 | = | 160.8 | nM | 6.79 |
| CHEMBL319541 | — | IC50 | = | 245.3 | nM | 6.61 |
| CHEMBL99581 | — | IC50 | = | 387.5 | nM | 6.41 |
| CHEMBL100366 | — | IC50 | = | 780.4 | nM | 6.11 |
| CHEMBL99414 | — | IC50 | = | 2193.5 | nM | 5.66 |
| CHEMBL317162 | — | IC50 | = | 2847.5 | nM | 5.55 |
| CHEMBL75919 | — | IC50 | = | 3500.5 | nM | 5.46 |
| CHEMBL99284 | — | IC50 | = | 5654.5 | nM | 5.25 |
| CHEMBL76640 | (+)-PHYSOSTIGMINE | IC50 | = | 9887.0 | nM | 5.00 |
| CHEMBL99655 | — | IC50 | = | 11223.0 | nM | 4.95 |