Compound Detail
CHEMBL76640
(+)-PHYSOSTIGMINE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL76640 |
| Name | (+)-PHYSOSTIGMINE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PIJVFDBKTWXHHD-AWKYBWMHSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
275.4
MW (Da)
1.77
ALogP
4
HBA
1
HBD
44.8
PSA (Ų)
0.85
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 5.6
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Cholinesterase CHEMBL1914 | IC50 | 5.6 | 5.6 | 2489.0 | 2 |
| Acetylcholinesterase CHEMBL220 | IC50 | 5.0 | 5.0 | 9887.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Cholinesterase | IC50 | = | 2490.0 | nM | 5.6 | Anticholinesterase activity against plasma Butyrylcholinesterase (BChE) in human... | 9632370 |
| Cholinesterase | IC50 | = | 2489.0 | nM | 5.6 | Inhibition of human Butyrylcholinesterase | 9288171 |
| Acetylcholinesterase | IC50 | = | 9890.0 | nM | 5.0 | Anticholinesterase activity against erythrocyte acetylcholinesterase (AChE) in h... | 9632370 |
| Acetylcholinesterase | IC50 | = | 9887.0 | nM | 5.0 | Inhibition of human acetylcholinesterase from erythrocytes (RBC) | 9288171 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9632370 | 10.1021/jm9800494 | Acetylcholinesterase | 1 |
| 9632370 | 10.1021/jm9800494 | Cholinesterase | 1 |
| 9288171 | 10.1021/jm970210v | Acetylcholinesterase | 1 |
| 9288171 | 10.1021/jm970210v | Cholinesterase | 1 |
Data from ChEMBL 36 via Core Engine