Assay Detail
Binding
CHEMBL644708
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Inhibition against ACE.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
PRO_LIGAND: an approach to de novo molecular design. 2. Design of novel molecules from molecular field analysis (MFA) models and pharmacophores.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.33 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL340152 | — | — | 1 | 6.16 |
| CHEMBL91777 | VALYLTRYPTOPHAN | — | 1 | 5.77 |
| CHEMBL340119 | — | — | 1 | 5.64 |
| CHEMBL91090 | — | — | 1 | 5.43 |
| CHEMBL128399 | — | — | 1 | 5.38 |
| CHEMBL129432 | — | — | 1 | 4.80 |
| CHEMBL338446 | — | — | 1 | 4.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL340152 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL91777 | VALYLTRYPTOPHAN | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL340119 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL91090 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL128399 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL129432 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL338446 | — | IC50 | = | 78000.0 | nM | 4.11 |