Assay Detail
Binding
CHEMBL644734
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Inhibitory activity on Angiotensin I converting enzyme (ACE) obtained from pig renal cortex and hippuryl-histidyl-leucine as substrate
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Studies on angiotensin converting enzyme inhibitors. 4. Synthesis and angiotensin converting enzyme inhibitory activities of 3-acyl-1-alkyl-2-oxoimidazolidine-4-carboxylic acid derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.06 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL328378 | — | — | 1 | 8.68 |
| CHEMBL421581 | — | — | 1 | 5.82 |
| CHEMBL91777 | VALYLTRYPTOPHAN | — | 1 | 5.80 |
| CHEMBL102044 | — | — | 1 | 5.00 |
| CHEMBL317094 | IMIDAPRIL | 4.0 | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL328378 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL421581 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL91777 | VALYLTRYPTOPHAN | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL102044 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL317094 | IMIDAPRIL | IC50 | = | 9900.0 | nM | 5.00 |