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Compound Detail

CHEMBL317094

IMIDAPRIL
💊 Approved Drug
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💊 Approved Drug
CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N1C(=O)N(C)C[C@H]1C(=O)O
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL317094
Name IMIDAPRIL
Phase Approved
Structure Type MOL
InChI Key KLZWOWYOHUKJIG-BPUTZDHNSA-N
Therapeutic ✓ Yes
Active Moiety CHEMBL99701

Known Names

Hipertene Imidapril Imidapril hcl Imidapril hydrochloride Imidapril monohydrochloride TA 6366 TA-6366 Tanatril
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
20
Publications
8
Known Names
3
Indications
1
Mechanisms

Molecular Properties

405.4
MW (Da)
0.88
ALogP
6
HBA
2
HBD
116.2
PSA (Ų)
0.59
QED
0
Ro5 Violations
9
Rot. Bonds

Drug Information

Molecule Type Small molecule
First Approval 1993
Availability Unknown
Chirality Single Enantiomer

Routes of Administration

Oral

Flags

Natural Product Prodrug
USAN Stem -pril

Extended Properties

Molecular Formula C20H27N3O6
MW 405.45
Aromatic Rings 1
Heavy Atoms 29
NP-Likeness -0.11

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Angiotensin-converting enzyme inhibitor INHIBITOR Angiotensin-converting enzyme ✓ ✓

Indications

Cardiovascular Diseases Essential Hypertension Polycystic Kidney, Autosomal Dominant

ATC Classification

C09AA16
imidapril
Level 1: CARDIOVASCULAR SYSTEM
Level 2: AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM

Activity Summary

IC50 1 meas. best 5.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Angiotensin-converting enzyme
CHEMBL1808
 IC50 5.0 5.0 9900.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Angiotensin-converting enzyme IC50 = 9900.0 nM 5.0 Inhibitory activity on Angiotensin I converting enzyme (ACE) obtained from pig r... 2913292

Literature References

PubMed DOI Target Context # Activities
2913292 10.1021/jm00122a003 Rattus norvegicus 22
20014752 10.1021/tx900326k Hepatotoxicity 3
37468498 10.1038/s41467-023-40064-9 Nuclear receptor subfamily 1 group I member 2 2
37468498 10.1038/s41467-023-40064-9 Alpha-1A adrenergic receptor 2
37468498 10.1038/s41467-023-40064-9 Muscarinic acetylcholine receptor M2 2
37468498 10.1038/s41467-023-40064-9 5-hydroxytryptamine receptor 2A 2
37468498 10.1038/s41467-023-40064-9 5-hydroxytryptamine receptor 2B 2
37468498 10.1038/s41467-023-40064-9 5-hydroxytryptamine receptor 1A 2
37468498 10.1038/s41467-023-40064-9 Gamma-aminobutyric acid receptor subunit alpha-1 2
37468498 10.1038/s41467-023-40064-9 Alpha-2A adrenergic receptor 2
37468498 10.1038/s41467-023-40064-9 Progesterone receptor 2
37468498 10.1038/s41467-023-40064-9 Cannabinoid receptor 1 2
- 10.6019/CHEMBL4808148 Histone deacetylase 6 2
- 10.6019/CHEMBL4495565 SARS-CoV-2 2
37468498 10.1038/s41467-023-40064-9 Androgen receptor 2
19932971 10.1016/j.bmc.2009.10.052 Liver carboxylesterase 1 2
37468498 10.1038/s41467-023-40064-9 Glutamate receptor ionotropic, NMDA 1 1
37468498 10.1038/s41467-023-40064-9 Beta-1 adrenergic receptor 1
37468498 10.1038/s41467-023-40064-9 Beta-2 adrenergic receptor 1
37468498 10.1038/s41467-023-40064-9 Sodium-dependent dopamine transporter 1

Data from ChEMBL 36 via Core Engine