Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL644757

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Inhibitory potency to aminopyrine N-demethylase activity (P450) in hepatic microsomes from phenobarbitone-induced rats.
ChEMBL ↗
82
Total Activities
82
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Rattus norvegicus
Tissue Liver
Subcellular Microsomes
Confidence 9 — Direct single protein target
Curated By Expert

Target

Cytochrome P450 2B1 (CHEMBL3335) ↗
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Inhibition of rat hepatic microsomal aminopyrine N-demethylase activity by benzimidazole derivatives. Quantitative structure-activity relationships.
Murray M, Ryan AJ, Little PJ.
J Med Chem (1982) 25 : 887 -892
PubMed 7120277 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 82 4.46 4.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL169709 — — 1 4.96
CHEMBL169858 — — 1 4.96
CHEMBL353984 — — 1 4.92
CHEMBL355666 — — 1 4.82
CHEMBL158007 — — 1 4.82
CHEMBL169203 — — 1 4.82
CHEMBL355669 — — 1 4.74
CHEMBL172621 — — 1 4.72
CHEMBL170993 — — 1 4.70
CHEMBL171325 — — 1 4.66
CHEMBL354972 — — 1 4.64
CHEMBL169212 — — 1 4.64
CHEMBL170998 — — 1 4.60
CHEMBL355280 — — 1 4.60
CHEMBL170513 — — 1 4.60
CHEMBL424396 — — 1 4.59
CHEMBL353595 — — 1 4.59
CHEMBL345675 — — 1 4.59
CHEMBL172156 — — 1 4.57
CHEMBL172114 — — 1 4.57
CHEMBL354514 — — 1 4.55
CHEMBL169149 — — 1 4.54
CHEMBL170771 — — 1 4.54
CHEMBL352972 — — 1 4.52
CHEMBL353945 — — 1 4.52
CHEMBL171191 — — 1 4.49
CHEMBL171596 — — 1 4.41
CHEMBL170910 — — 1 4.38
CHEMBL169701 — — 1 4.35
CHEMBL355159 — — 1 4.35

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL169709 — IC50 = 10964.78 nM 4.96
CHEMBL169858 — IC50 = 10964.78 nM 4.96
CHEMBL353984 — IC50 = 12022.64 nM 4.92
CHEMBL355666 — IC50 = 15135.61 nM 4.82
CHEMBL158007 — IC50 = 15135.61 nM 4.82
CHEMBL169203 — IC50 = 15135.61 nM 4.82
CHEMBL355669 — IC50 = 18197.01 nM 4.74
CHEMBL172621 — IC50 = 19054.61 nM 4.72
CHEMBL170993 — IC50 = 19952.62 nM 4.70
CHEMBL171325 — IC50 = 21877.62 nM 4.66
CHEMBL354972 — IC50 = 22908.68 nM 4.64
CHEMBL169212 — IC50 = 22908.68 nM 4.64
CHEMBL170513 — IC50 = 25118.86 nM 4.60
CHEMBL355280 — IC50 = 25118.86 nM 4.60
CHEMBL170998 — IC50 = 25118.86 nM 4.60
CHEMBL424396 — IC50 = 25703.96 nM 4.59
CHEMBL345675 — IC50 = 25703.96 nM 4.59
CHEMBL353595 — IC50 = 25703.96 nM 4.59
CHEMBL172156 — IC50 = 26915.35 nM 4.57
CHEMBL172114 — IC50 = 26915.35 nM 4.57
CHEMBL354514 — IC50 = 28183.83 nM 4.55
CHEMBL169149 — IC50 = 28840.32 nM 4.54
CHEMBL170771 — IC50 = 28840.32 nM 4.54
CHEMBL352972 — IC50 = 30199.52 nM 4.52
CHEMBL353945 — IC50 = 30199.52 nM 4.52
CHEMBL171191 — IC50 = 32359.37 nM 4.49
CHEMBL171596 — IC50 = 38904.51 nM 4.41
CHEMBL170910 — IC50 = 41686.94 nM 4.38
CHEMBL169701 — IC50 = 44668.36 nM 4.35
CHEMBL355159 — IC50 = 44668.36 nM 4.35
CHEMBL155867 — IC50 = 50118.72 nM 4.30
CHEMBL171977 — IC50 = 53703.18 nM 4.27
CHEMBL415754 — IC50 = 53703.18 nM 4.27
CHEMBL171759 — IC50 = 53703.18 nM 4.27
CHEMBL153535 — IC50 = 54954.09 nM 4.26
CHEMBL353807 — IC50 = 54954.09 nM 4.26
CHEMBL169912 — IC50 = 56234.13 nM 4.25
CHEMBL72683 — IC50 = 64565.42 nM 4.19
CHEMBL171992 — IC50 = 67608.3 nM 4.17
CHEMBL171673 — IC50 = 67608.3 nM 4.17
CHEMBL424581 — IC50 = 69183.1 nM 4.16
CHEMBL303252 — IC50 = 81283.05 nM 4.09
CHEMBL71855 — IC50 = 81283.05 nM 4.09
CHEMBL171135 — IC50 = 91201.08 nM 4.04
CHEMBL355063 BENDAZOL IC50 = 91201.08 nM 4.04
CHEMBL352521 — IC50 = 100000.0 nM 4.00
CHEMBL171620 — IC50 = 100000.0 nM 4.00
CHEMBL353026 — IC50 = 218776.16 nM -
CHEMBL156439 — IC50 = 181970.09 nM -
CHEMBL303714 — IC50 = 457088.19 nM -