Assay Detail
Binding
CHEMBL644783
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Binding affinity against Alpha-1 adrenergic receptor, activity is expressed as IC50 values
15
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Enhanced D1 affinity in a series of piperazine ring substituted 1-piperazino-3-arylindans with potential atypical antipsychotic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.78 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL136630 | — | — | 2 | 8.41 |
| CHEMBL136722 | — | — | 1 | 8.36 |
| CHEMBL136235 | — | — | 2 | 8.33 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 8.04 |
| CHEMBL137960 | — | — | 2 | 8.00 |
| CHEMBL136683 | — | — | 2 | 7.92 |
| CHEMBL136226 | — | — | 1 | 7.85 |
| CHEMBL137536 | — | — | 1 | 7.82 |
| CHEMBL343282 | — | — | 1 | 7.60 |
| CHEMBL136891 | — | — | 1 | 7.03 |
| CHEMBL136190 | — | — | 1 | 6.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL136630 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL136722 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL136235 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL136630 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL42 | CLOZAPINE | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL137960 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL136235 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL136683 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL136226 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL137536 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL137960 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL343282 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL136683 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL136891 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL136190 | — | IC50 | = | 970.0 | nM | 6.01 |