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Compound Detail

CHEMBL136190

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C[C@H]1N(C)CCc2cc(Cl)c(O)cc2[C@@]1(C)c1ccccc1

Basic Information

ChEMBL ID CHEMBL136190
Phase Preclinical
Structure Type MOL
InChI Key SQJIIXSSALZMDR-BFUOFWGJSA-N
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names

Molecular Properties

315.8
MW (Da)
4.23
ALogP
2
HBA
1
HBD
23.5
PSA (Ų)
0.85
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C19H22ClNO
MW 315.84
Aromatic Rings 2
Heavy Atoms 22
NP-Likeness 0.54

Activity Summary

IC50 4 meas. best 9.43

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
D(1A) dopamine receptor
CHEMBL265
IC50 9.43 9.43 0.4 1
5-hydroxytryptamine receptor 2A
CHEMBL322
IC50 7.85 7.85 14.0 1
Adrenergic receptor alpha-1
CHEMBL1907610
IC50 6.01 6.01 970.0 1
D(2) dopamine receptor
CHEMBL339
IC50 5.5 5.5 3200.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
7473566 10.1021/jm00022a004 D(1A) dopamine receptor 2
7473566 10.1021/jm00022a004 D(2) dopamine receptor 2
7473566 10.1021/jm00022a004 Dopamine receptors; D1 & D2 2
7473566 10.1021/jm00022a004 5-hydroxytryptamine receptor 2A 1
7473566 10.1021/jm00022a004 Adrenergic receptor alpha-1 1
7473566 10.1021/jm00022a004 Mus musculus 1
7473566 10.1021/jm00022a004 Rattus norvegicus 1

Data from ChEMBL 36 via Core Engine